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In this lecture, the speaker demonstrates Neurokernel's module interfacing feature by using it to integrate independently developed models of olfactory and vision LPUs based upon experimentally obtained connectivity information.

Difficulty level: Intermediate
Duration: 29:56
Speaker: : Aurel A. Lazar

In this talk the speakers will give a brief introduction of the Fenix Infrastructure and Service Offering, before focusing on Data Safety. The speaker will take the participants through the ETHZ-CSCS offering for EBRAINS and all the HBP Communities highlighting the Infrastructure role in a service implementation in respect of Security. Particular attention will be on showing what tools ETHZ-CSCS provides to a Portal/Service provider such as EBRAINS, MIP/HIP, TVB, NRP amongst others. Finally there will be given a quick glimpse into the future and the role that “multi-tenancy” will play.

Difficulty level: Intermediate
Duration: 20:05

This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health. 

Difficulty level: Intermediate
Duration: 1:47:22

This tutorial introduces pipelines and methods to compute brain connectomes from fMRI data. With corresponding code and repositories, participants can follow along and learn how to programmatically preprocess, curate, and analyze functional and structural brain data to produce connectivity matrices. 

Difficulty level: Intermediate
Duration: 1:39:04

This lecture and tutorial focuses on measuring human functional brain networks, as well as how to account for inherent variability within those networks. 

Difficulty level: Intermediate
Duration: 50:44
Speaker: : Caterina Gratton

This lecture presents an overview of functional brain parcellations, as well as a set of tutorials on bootstrap agregation of stable clusters (BASC) for fMRI brain parcellation.

Difficulty level: Advanced
Duration: 50:28
Speaker: : Pierre Bellec

This lecture focuses on ontologies for clinical neurosciences.

Difficulty level: Intermediate
Duration: 21:54

This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.

Difficulty level: Intermediate
Duration: 1:09:33
Speaker: : Sean Hill

This is a continuation of the talk on the cellular mechanisms of neuronal communication, this time at the level of brain microcircuits and associated global signals like those measureable by electroencephalography (EEG). This lecture also discusses EEG biomarkers in mental health disorders, and how those cortical signatures may be simulated digitally.

Difficulty level: Intermediate
Duration: 1:11:04
Speaker: : Etay Hay

This lecture provides an introduction to entropy in general, and multi-scale entropy (MSE) in particular, highlighting the potential clinical applications of the latter. 

Difficulty level: Intermediate
Duration: 39:05
Speaker: : Jil Meier

This lecture provides an general introduction to epilepsy, as well as why and how TVB can prove useful in building and testing epileptic models. 

Difficulty level: Intermediate
Duration: 37:12
Speaker: : Julie Courtiol

This lecture covers the rationale for developing the DAQCORD, a framework for the design, documentation, and reporting of data curation methods in order to advance the scientific rigour, reproducibility, and analysis of data.

Difficulty level: Intermediate
Duration: 17:08
Speaker: : Ari Ercole

This talks presents an overview of the potential for data federation in stroke research.

Difficulty level: Intermediate
Duration: 21:37

This lecture explains the need for data federation in medicine and how it can be achieved.

Difficulty level: Intermediate
Duration: 27:09
Speaker: : Philippe Ryvlin

In this session the Medical Informatics Platform (MIP) federated analytics is presented. The current and future analytical tools implemented in the MIP will be detailed along with the constructs, tools, processes, and restrictions that formulate the solution provided. MIP is a platform providing advanced federated analytics for diagnosis and research in clinical neuroscience research. It is targeting clinicians, clinical scientists and clinical data scientists. It is designed to help adopt advanced analytics, explore harmonized medical data of neuroimaging, neurophysiological and medical records as well as research cohort datasets, without transferring original clinical data. It can be perceived as a virtual database that seamlessly presents aggregated data from distributed sources, provides access and analyze imaging and clinical data, securely stored in hospitals, research archives and public databases. It leverages and re-uses decentralized patient data and research cohort datasets, without transferring original data. Integrated statistical analysis tools and machine learning algorithms are exposed over harmonized, federated medical data.

Difficulty level: Intermediate
Duration: 15:05

The Medical Informatics Platform (MIP) is a platform providing federated analytics for diagnosis and research in clinical neuroscience research. The federated analytics is possible thanks to a distributed engine that executes computations and transfers information between the members of the federation (hospital nodes). In this talk the speaker will describe the process of designing and implementing new analytical tools, i.e. statistical and machine learning algorithms.  Mr. Sakellariou will further describe the environment in which these federated algorithms run, the challenges and the available tools, the principles that guide its design and the followed general methodology for each new algorithm. One of the most important challenges which are faced is to design these tools in a way that does not compromise the privacy of the clinical data involved. The speaker will show how to address the main questions when designing such algorithms: how to decompose and distribute the computations and what kind of information to exchange between nodes, in order to comply with the privacy constraint mentioned above. Finally, also the subject of validating these federated algorithms will be briefly touched.

Difficulty level: Intermediate
Duration: 20:26
Speaker: : Jason Skellariou

The Medical Informatics Platform (MIP) Dementia had been installed in several memory clinics across Europe allowing them to federate their real-world databases. Research open access databases had also been integrated such as ADNI (Alzheimer’s Dementia Neuroimaging Initiative), reaching a cumulative case load of more than 5,000 patients (major cognitive disorder due to Alzheimer’s disease, other major cognitive disorder, minor cognitive disorder, controls). The statistic and machine learning tools implemented in the MIP allowed researchers to conduct easily federated analyses among Italian memory clinics (Redolfi et al. 2020) and also across borders between the French (Lille), the Swiss (Lausanne) and the Italian (Brescia) datasets.

Difficulty level: Intermediate
Duration: 16:44
Speaker: : Mélanie Leroy

This lecture talks about the usage of knowledge graphs in hospitals and related challenges of semantic interoperability.

Difficulty level: Intermediate
Duration: 24:32

This lecture discusses risk-based anonymization approaches for medical research.

Difficulty level: Intermediate
Duration: 15:43
Speaker: : Fabian Prasser

This lecture discusses the the importance and need for data sharing in clinical neuroscience.

Difficulty level: Intermediate
Duration: 25:22
Speaker: : Thomas Berger