The Virtual Brain is an open-source, multi-scale, multi-modal brain simulation platform. In this lesson, you get introduced to brain simulation in general and to The Virtual brain in particular. Prof. Ritter will present the newest approaches for clinical applications of The Virtual brain - that is, for stroke, epilepsy, brain tumors and Alzheimer’s disease - and show how brain simulation can improve diagnostics, therapy and understanding of neurological disease.

The concept of neural masses, an application of mean field theory, is introduced as a possible surrogate for electrophysiological signals in brain simulation. The mathematics of neural mass models and their integration to a coupled network are explained. Bifurcation analysis is presented as an important technique in the understanding of non-linear systems and as a fundamental method in the design of brain simulations. Finally, the application of the described mathematics is demonstrated in the exploration of brain stimulation regimes.

The simulation of the virtual epileptic patient is presented as an example of advanced brain simulation as a translational approach to deliver improved results in clinics. The fundamentals of epilepsy are explained. On this basis, the concept of epilepsy simulation is developed. By using an iPython notebook, the detailed process of this approach is explained step by step. In the end, you are able to perform simple epilepsy simulations your own.

A brief overview of the Python programming language, with an emphasis on tools relevant to data scientists. This lecture was part of the 2018 Neurohackademy, a 2-week hands-on summer institute in neuroimaging and data science held at the University of Washington eScience Institute.

Félix-Antoine Fortin from Calcul Québec gives an introduction to high-performance computing with the Compute Canada network, first providing an overview of use cases for HPC and then a hand-on tutorial.  Though some examples might seem specific to the Calcul Québec, all computing clusters in the Compute Canada network share the same software modules and environments.

The lesson was given in the context of the BrainHack School 2020.

The Canadian Open Neuroscience Platform (CONP) Portal is a web interface that facilitates open science for the neuroscience community by simplifying global access to and sharing of datasets and tools. The Portal internalizes the typical cycle of a research project, beginning with data acquisition, followed by data processing with published tools, and ultimately the publication of results with a link to the original dataset.

In this video, Samir Das and Tristan Glatard give a short overview of the main features of the CONP Portal.

Shawn Brown presents an overview of CBRAIN, a web-based platform that allows neuroscientists to perform computationally intensive data analyses by connecting them to high-performance-computing facilities across Canada and around the world.

This talk was given in the context of a Ludmer Centre event in 2019.

Estefany Suárez provides a conceptual overview of the rudiments of machine learning, including its bases in traditional statistics and the types of questions it might be applied to.

The lesson was presented in the context of the BrainHack School 2020.

Jake Vogel gives a hands-on, Jupyter-notebook-based tutorial to apply machine learning in Python to brain-imaging data.

The lesson was presented in the context of the BrainHack School 2020.

Gael Varoquaux presents some advanced machine learning algorithms for neuroimaging, while addressing some real-world considerations related to data size and type.

The lesson was presented in the context of the BrainHack School 2020.

Dr. Guangyu Robert Yang describes how Recurrent Neural Networks (RNNs) trained with machine learning techniques on cognitive tasks have become a widely accepted tool for neuroscientists. In comparison to traditional computational models in neuroscience, RNNs can offer substantial advantages at explaining complex behavior and neural activity patterns. Their use allows rapid generation of mechanistic hypotheses for cognitive computations. RNNs further provide a natural way to flexibly combine bottom-up biological knowledge with top-down computational goals into network models. However, early works of this approach are faced with fundamental challenges. In this talk, Dr. Guangyu Robert Yang discusses some of these challenges, and several recent steps that we took to partly address them and to build next-generation RNN models for cognitive neuroscience.​

This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.

This lecture will provide an overview of neuroimaging techniques and their clinical applications.

This lecture will provide an overview of neuroimaging techniques and their clinical applications

This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases

This lecture provides an overview of depression (epidemiology and course of the disorder), clinical presentation, somatic co-morbidity, and treatment options.

How genetics can contribute to our understanding of psychiatric phenotypes.

The lecture focuses on rationale for employing neuroimaging methods for movement disorders

An overview of some of the essential concepts in neuropharmacology (e.g. receptor binding, agonism, antagonism), an introduction to pharmacodynamics and pharmacokinetics, and an overview of the drug discovery process relative to diseases of the Central Nervous System.

This module explores sensation in the brain: what organs are involved, sensory pathways, processing centers, and theories of integration. We cover sensory transduction, vision, audition olfaction, gustation, and somatosensation.