Brief introduction to Research Resource Identifiers (RRIDs), persistent and unique identifiers for referencing a research resource.
Introduction to the Brain Imaging Data Structure (BIDS): a standard for organizing human neuroimaging datasets. This lecture was part of the 2018 Neurohackademy, a 2-week hands-on summer institute in neuroimaging and data science held at the University of Washington eScience Institute.
DAQCORD is a framework for the design, documentation and reporting of data curation methods in order to advance the scientific rigour, reproducibility and analysis of the data. This lecture covers the rationale for developing the framework, the process in which the framework was developed, and ends with a presentation of the framework. While the driving use case for DAQCORD was clinical traumatic brain injury research, the framework is applicable to clinical studies in other domains of clinical neuroscience research.
Lecture on functional brain parcellations and a set of tutorials on bootstrap agregation of stable clusters (BASC) for fMRI brain parcellation which were part of the 2019 Neurohackademy, a 2-week hands-on summer institute in neuroimaging and data science held at the University of Washington eScience Institute.
Since their introduction in 2016, the FAIR data principles have gained increasing recognition and adoption in global neuroscience. FAIR defines a set of high-level principles and practices for making digital objects, including data, software, and workflows, Findable, Accessible, Interoperable, and Reusable. But FAIR is not a specification; it leaves many of the specifics up to individual scientific disciplines to define. INCF has been leading the way in promoting, defining, and implementing FAIR data practices for neuroscience. We have been bringing together researchers, infrastructure providers, industry, and publishers through our programs and networks. In this session, we will hear some perspectives on FAIR neuroscience from some of these stakeholders who have been working to develop and use FAIR tools for neuroscience. We will engage in a discussion on questions such as: how is neuroscience doing with respect to FAIR? What have been the successes? What is currently very difficult? Where does neuroscience need to go?
This lecture covers FAIR atlases, from their background, their construction, and how they can be created in line with the FAIR principles.
This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.
This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases
This lecture provides an overview of depression (epidemiology and course of the disorder), clinical presentation, somatic co-morbidity, and treatment options.
How genetics can contribute to our understanding of psychiatric phenotypes.
The lecture focuses on rationale for employing neuroimaging methods for movement disorders
An overview of some of the essential concepts in neuropharmacology (e.g. receptor binding, agonism, antagonism), an introduction to pharmacodynamics and pharmacokinetics, and an overview of the drug discovery process relative to diseases of the Central Nervous System.
Longitudinal Online Research and Imaging System (LORIS) is a web-based data and project management software for neuroimaging research studies. It is an open source framework for storing and processing behavioural, clinical, neuroimaging and genetic data. LORIS also makes it easy to manage large datasets acquired over time in a longitudinal study, or at different locations in a large multi-site study.
The Medical Informatics Platform (MIP) is a platform providing federated analytics for diagnosis and research in clinical neuroscience research. The federated analytics is possible thanks to a distributed engine that executes computations and transfers information between the members of the federation (hospital nodes). In this talk the speaker will describe the process of designing and implementing new analytical tools, i.e. statistical and machine learning algorithms. Mr. Sakellariou will further describe the environment in which these federated algorithms run, the challenges and the available tools, the principles that guide its design and the followed general methodology for each new algorithm. One of the most important challenges which are faced is to design these tools in a way that does not compromise the privacy of the clinical data involved. The speaker will show how to address the main questions when designing such algorithms: how to decompose and distribute the computations and what kind of information to exchange between nodes, in order to comply with the privacy constraint mentioned above. Finally, also the subject of validating these federated algorithms will be briefly touched.
Introduction to the types of glial cells, homeostasis (influence of cerebral blood flow and influence on neurons), insulation and protection of axons (myelin sheath; nodes of Ranvier), microglia and reactions of the CNS to injury.
Introduction to neurons, synaptic transmission, and ion channels.
This lecture covers: integrating information within a network, modulating and controlling networks, functions and dysfunctions of hippocampal networks, and the integrative network controlling sleep and arousal.
This lecture focuses on the comprehension of nociception and pain sensation. It highlights how the somatosensory system and different molecular partners are involved in nociception and how nociception and pain sensation are studied in rodents and humans and the development of pain therapy.