The natural history of neurodegenerative disease I

This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases. Speaker: Nir Giladi.

By HBP Education Programme
Published Mar, 2018

Learning materials

External links


Lecture slides


Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Lewy body dementia, Huntington's disease and motor neuron disease have similar pathophysiologies of protein misfolding, accumulation of protein aggregates and a slow, progressive course of neuronal cell death. In addition, these and other disorders have a long prodromal stage, when the pathological process is slowly progressing but clinically unrecognized. Better characterization of new and highly sensitive biological markers now enables the detection of subjects at risk or in the earliest prodromal stages of the disease. Early detection of neurodegeneration will enable future medicine to apply new concepts of intervention, moving from the current symptomatic and palliative approaches to disease-modifying therapy and even disease prevention. 

Topics covered:

  1. The aging brain and its diseases
  2. Prevalence of neurodegenerative diseases
  3. Early signs of neurodegenerative diseases
  4. Protein aggregation and cellular degeneration in neurodegenerative diseases
  5. Pathophysiology of neurodegenerative diseases