Computational principles of axon guidance

This lecture covers computational principles that growth cones employ to detect and respond to environmental chemotactic gradients, focusing particularly on growth cone shape dynamics. Speaker: Geoff Goodhill

By INCF
Published Aug, 2014

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Workshop lecture at Neuroinformatics 2014 in Leiden, The Netherlands
Workshop title: Building the Brain
Talk title: Computational principles of axon guidance
Speaker: Geoff Goodhill

Talk abstract:
Correct brain function relies on the accurate guidance of growing axons to their appropriate targets during development. At the tips of developing axons, growth cones are highly dynamic structures with exquisite sensitivity to environmental cues. I will discuss our recent experimental and theoretical work attempting to uncover the computational principles that growth cones employ to detect and respond to environmental chemotactic gradients, focusing particularly on growth cone shape dynamics. I will discuss how just a few shape primitives capture most of the shape variance of growth cones, and that periodic oscillations play a critical role in their shape dynamics.